The median annual wage for pharmacists working in San Luis Obispo, CA, sits at $172,860, per BLS survey data. It runs 24% above the national median of $139,410 for this occupation — pay here is notably stronger than the U.S. average. The middle 50% land between $154,690 and $202,780 — a 48,090 range that reflects differences in seniority, employer type, and specialization. The catch: San Luis Obispo is roughly in line with the national cost of living (cost index 100 against a 100 baseline), so that headline number buys less than it would elsewhere. On an hourly basis that is about $83.11, useful for comparing contract or part-time offers.

For context, the national median for pharmacists across all U.S. metros in our data is $139,410.